Metrorrhagia and precocious puberty revealing primary hypothyroidism in a child with Down's syndrome.
نویسندگان
چکیده
We report a child with Down's syndrome in whom metrorrhagia and precocious puberty revealed primary autoimmune hypothyroidism. The patient had a decreased growth velocity, exaggerated weight gain, bone age delay, and bilaterally enlarged multicystic ovaries. Delays in the diagnosis and treatment of hypothyroidism can lead to this peculiar presentation.
منابع مشابه
Precocious Puberty: An Unusual Presentation of Hypothyroidism
Hypothyroidism is usually associated with delayed pubertal development but in rare occasions precocious puberty may ensue which is seen in cases of prolonged and untreated hypothyroidism. This is also called the Van Wyk Grumbach syndrome. Here we present 4 cases of precocious puberty due to hypothyroidism.
متن کاملA Case of Van Wyk-Grumbach Syndrome
In boys precocious puberty is defined as the development of secondary sexual characters before 9 year of age. In girls, the development of breasts (thelarche) before 7.5 year, the development of pubic hairs (pubarche) before 8.5 year or menarche before the age of 9.5 year is considered precocious [1]. Hypothyroidism is usually associated with delayed puberty and rarely with precocious puberty [...
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Background: This study was performed in order to detect the frequency of different types of precocious puberty, predisposing factors and to show which group of patients need to treatment. Materials and Methods: In this study, 74 patients who referred to pediatric endocrine clinic of Imam Khomeini Hospital and private office from 1993-2000 were assessed. A complete history was taken and physical...
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Primary hypothyroidism is frequently associated with delayed puberty. However, precocious puberty is known to occur in some rare cases of hypothyroidism untreated for a long time. A female patient with Down syndrome aged 2 years and 9 months was referred with the symptom of vaginal bleeding continuing for 1 week. In her history, there were no symptoms suggesting trauma, foreign body, urinary tr...
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عنوان ژورنال:
- Archives of disease in childhood
دوره 88 4 شماره
صفحات -
تاریخ انتشار 2003